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11. Cancer: Most & Least Compatible
Most
Cancer is compatible with fellow Water-signs Scorpio and Pisces. Specifically, Pisces and Cancer share deep emotional vulnerability, and Pisces will understand Cancer's mood swings. 

Cancer also works well with Taurus and Virgo, who both will help Cancer feel grounded and secure. Capricorn, Cancer's opposite, is also an exceptional match for the same reasons as Taurus and Virgo.

Least
Typically, Aries and Libra are considered the least compatible with Cancer. Aries' need to be free and on-the-go will likely cause home-body Cancer some anxiety.