Rory And Lane In 'Gilmore Girls'
Of all the fictional friendships on this list, the one between Rory Gilmore and Lane Kim from Gilmore Girls has got to be one of my favorites. From experiencing firsts like love and breakups, to fighting with their parents (usually culminating in Lane sneaking out of her house to escape her overbearing mother), these besties stayed joined at the hip through all the ups and downs on the show and in both of their lives.

They also fast-talked their way through it all, along with Lorelai, with a witty aplomb that television has not seen the likes of, before or since.
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