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#19: Ben Sullivan's Death On 'Scrubs'
Ben Sullivan, Dr. Cox's best friend, had been in remission for some time, but had failed to go to his annual checkups to make sure he was still cancer-free. In the episode we find out that Ben finally goes to the hospital thanks to Dr. Cox's prodding, and he dies there soon after — his cancer came back and it was aggressively spreading without him knowing. 

The episode was a stark reminder that sometimes illnesses can't be overcome, and watching the usual stony-faced Dr. Cox grieve over his friend really gets you.
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