Brooke And Peyton In 'One Tree Hill'
These two also saw their fair share of ups and downs, but One Tree Hill's Brooke Davis (Sophia Bush) and Peyton Sawyer (Hilarie Burton) were always there for each other when it mattered most. 
B. Davis and P. Sawyer saw each other through breakups and heartbreaks (often over the same guy, which I still find problematic, but again, it was a dark time before today's more PC era began), even fighting off Peyton's psychotic "brother" on prom night. Man, that episode was memorable!

Plus, their character arcs were nothing short of legendary, especially Brooke's transformation from ditzy cheerleader to badass, feminist businesswoman. In all honesty, we'll never not miss One Tree Hill's most fabulous duo.