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'Will & Grace'
Legendary sitcom Will & Grace isn't technically fully female-led, but Debra Messing was incredible in it, so we're including it in this list regardless. The show follows the titular besties, along with friends Karen and Jack, living their best lives in Manhattan — all while undergoing the pitfalls of love, sex, divorce, and more. Even better, the show is one of many who has received the modern reboot treatment, and has been renewed for two more seasons throughout 2020.