Restart slideshow

The Biggest Celebrity Breakups And Hookups Of 2021

Prev 32 of 35 Next
32. Breakup: John Mulaney And Anna Marie Tendler
This one hurts. After he went to rehab, the comedian ended his marriage. His wife told Page Six, "I am heartbroken that John has decided to end our marriage. I wish him support and success as he continues his recovery."