Restart slideshow

The Saddest Moments In TV History, Ranked

Prev 13 of 29 Next
#17: Denny Duquette's Death On 'Grey's Anatomy'
Grey's Anatomy has been running for 14 seasons now, which means there are hundreds of heart breaking scenes we can choose from. But one of the most wrenching was when Denny Duquette died from a stroke following a heart transplant. 

That moment where Izzie wraps herself around him on the hospital bed and weeps requires the tissues.