Midwest: St. Louis, Missouri
Though some may just think of its iconic arch, St. Louis has a ton to offer. From breweries big and small (Anheuser-Busch is located in St. Louis!), to museums and parks, you won't run out of things to do and see. And if you're looking for a fun place to go out, check out Laclede’s Landing — a 19th century riverfront area whose warehouses have been converted into nightclubs and restaurants.